Turkey Tail Mushroom: A Superfood For Gut Health

Last Updated on March 24, 2023

Turkey tail mushroom is most commonly praised for its capacity to boost resilience against viruses and pathogens. Still, one of the lesser-known abilities of this medicinal powerhouse is its benefits for optimal gut health.

We have long known that the food we eat gets converted into nutrients and energy so that we might lead rich and fulfilling lives. But more recently, researchers have discovered that our gut contains trillions of microbes, including bacteria, viruses, fungi, and protozoa, all of which are connected to immunity, homeostasis, mood, heart health, mental health, and general well-being.

Turkey Tail is starting to get greater notoriety for its capacity to restore the number and diversity of beneficial bacteria in the gut. It is a well-known prebiotic source largely because of its special PSP and PSK polysaccharides. Turkey tail, like the majority of mushrooms, also contains fiber, an indigestible component of plant foods that promotes a healthy digestive system.

Continue reading to discover the benefit of Turkey tail for gut health and simple ways to integrate it into your routine for vigor and wellness. But let’s begin by having a clearer understanding of gut health. 

What Is Turkey Tail Mushroom?

Turkey Tail mushroom, known by its scientific names such as Coriolus Versicolor or Trametes Versicolor, is a popular polypore fungus that has been used in traditional Asian medicine and North American herbalism for hundreds of years. Turkey Tail is a type of polypore mushroom that often grows on dead branches and stumps of hardwood trees. It’s a thin, rubbery, and semicircular mushroom with sometimes colorful striations on the upper surface. It is usually only 3-6 cm in width and forms longitudinal clusters and sometimes flower-like rosettes.

The mushroom is one of the most widely studied mushrooms with numerous health benefits such as

Today it has been deconstructed by science, vigorously studied in its chemistry, tested for biological activity, and placed through numerous clinical trials. 

It’s hard not to over-emphasize how important this mushroom is in the world of medicinal mushrooms. It’s the first medicinal mushroom many of us heard about, decades before medicinal mushrooms rose in popularity. Active compounds from Turkey Tail have the stamp of approval by many healthcare agencies and are even fully insured medications in places like Japan. Statistically, Turkey Tail mushrooms have likely improved health and probably even extended the lives of thousands of individuals.

turkey tail mushroom

What Is Gut Health?

Today, there is a lot of discussion in the health community about the significance of gut health and microbiome integrity. Sometimes when we hear the phrase “gut health,” we would instinctively assume that it refers to proper digestion, but this is really just the tip of the iceberg. About 70% of our immune response is controlled by our gut, and nearly all of the body’s serotonin—which affects both our mood and gastrointestinal function—is produced by the bacteria that live there.

You may think of the stomach as the base of good health for the entire body. The gut microbiome of each person is completely unique, similar to a fingerprint, and is made up of trillions of different microorganisms. In an ideal world, these microorganisms would cooperate harmoniously to support the overall health of the body, essentially assisting you in feeling better and having more energy.

A healthy and balanced gut microbiome helps us absorb nutrients from food, influences the brain and immune system, and also regulates our metabolism, heart health, skin health, hormone balance, and much more. Hippocrates, the father of natural medicine, rightly said over 2,500 years ago that “all disease begins in the gut.”

Benefits Of Turkey Tail Mushrooms For Gut Health

The gut microbiome is one of the most densely populated microbial communities globally. It contains many helpful bacteria that perform many essential tasks for maintaining human health. The composition and metabolic activity of the gut are balanced by various environmental factors, including nutrition, which is becoming a more important environmental element. Prebiotics and other essential dietary elements must be consumed to support healthy bacteria.
Prebiotics are nutrients that have been specifically fermented to encourage particular changes in the structure and function of the gut. They nourish the good bacteria, unlike probiotics, which are the beneficial bacteria in fiber-rich foods like fermented yogurt and kimchi. 
Turkey tail is beneficial for the gut because of its abundant contribution of prebiotics. It also has a positive influence on overall digestive health, which is why prebiotics is necessary for the probiotics to thrive.

Additionally, Turkey tail has a wide variety of naturally occurring substances that promote intestinal health, which is linked to a strong immune system. It contains more than 35 phenols and potent flavonoids, which are all abundant in antioxidants.

In particular, the mushroom is renowned for its strong natural polysaccharides, such as polysaccharide K (PSK) and polysaccharide peptide (PSP), which support healthy gut flora and the immunological barrier, which aids the immune system in protecting against disease.

Exploring The Research Behind Turkey Tail Mushroom Benefits

Increases diversity of gut bacteria

According to studies, Turkey Tail helps the gut recover by increasing the diversity of gut bacteria and supporting prebiotics. For instance, a study looked at the prebiotic effects of polysaccharopeptide PSP from Turkey tail on the gut flora[1]. 

Over the course of eight weeks, 2600 mg of PSP Turkey Tail extract was administered to 24 healthy volunteers. Each participant in the active treatment groups had their stools examined seven times over the course of eight weeks, compared to three times for the controls.

There were no significant changes in the gut microbiome for the control group (which got no therapy) (which makes sense). The group that received the Turkey tail extract showed improved gut bacterial alterations and signs of harmful bacteria’s growth being inhibited (like E. coli and Shigella). Turkey tail has won big here.

The group receiving antibiotics observed significant microbiome changes, including a rise in several harmful bacteria (the relationship between antibiotics and gut microbiota is complex; this is not a call to disregard current findings, however).

The findings supported the prebiotic activity of Turkey Tail by demonstrating clear and consistent improvements in the microbiome’s health and increases in “good” bacteria. Researchers have concluded that the mushroom can modify the composition of the human intestinal microbiome by acting as a prebiotic.

Additionally, other data suggest that PSP controls the gut microbiota by balancing the proportions of good bacteria in the intestines (2).

These findings were corroborated by a test-tube study (3). The researchers discovered  Turkey Tail extract changed the composition of the gut bacteria by increasing the population of helpful strains of gut bacteria Bifidobacterium and Lactobacillus and decreasing the population of potentially harmful bacteria Clostridium and Staphylococcus.

Alleviates colonic inflammation

In another animal study, the YZP protein isolated from fruiting bodies of Turkey tail mushrooms significantly alleviated the disease activity and colonic inflammation in acute colitis (4). The protein stimulated specific types of white blood cells, which exhibited anti-inflammatory effects beneficial in colitis. 

According to studies, PSP and PSK isolated from Turkey tail mushrooms have substantial immune-supporting properties that may be activated when they come into contact with immune cells in the digestive tract (5).

Primordial immune receptors in our digestive tract recognize the distinct beta-glucans.  It then triggers a complex immune response that includes increased monitoring and production of antibodies to target dangerous infections and immune system components that aren’t working as well as they should. 

Protein-bound beta-glucan (PBG), a substance found in turkey tail, may help prevent obesity, according to some research (6). For instance, a study on mice revealed that PBG prevented weight growth in those who consumed a high-fat diet. Based on the findings of the study, PBG may assist in balancing specific gut flora, which can help prevent obesity.

turkey tail mushrooms

A 2022 study found that Turkey tail inhibits some inflammatory pathways and may have an anti-colitis effect (7). The mushrooms were given orally to mice at a dosage of 200 mg per kg every day for four days. The tissues were subsequently removed for histological, biochemical, and molecular examinations.
Weight reduction and intestinal alterations were substantially less noticeable after Turkey tail treatment. The mushroom also enhanced the architecture of the colon and reduced the production of cytokines that cause inflammation. The findings of this study unequivocally demonstrate that this natural substance may be used as a dietary supplement to treat colitis.

In a nutshell, scientific research indicates that when using Turkey tail mushrooms as a supplement, the mycelium of the fungus may aid in a more effortless digestive process. The excellent prebiotics in the mushroom supports the microbiome. This indicates that it may promote the development of healthy bacteria in the body, such as acidophilus and bifidobacterium, which is even more advantageous for those with leaky gut syndrome.

Ways To Include Turkey Tail Into Your Gut Wellness Routine 

Like other functional fungi, Turkey tail truly shines when taken regularly, whether in food, as a tea, or in supplements. Even though it has a moderate, earthy flavor and is regarded as an edible fungus due to its slightly leathery texture, the mushroom is often taken in powder form.   
Turkey tail mushroom powders can be added to soups or a gut-nourishing smoothie. The powder is also a simple ingredient to incorporate into a major dish, snack, dessert, or beverage of your choice. It has a moderate flavor that some people describe as slightly sweet.

Stir it into bone broth, porridge, or hot tea in the colder months; in the warmer months, combine it into shakes or even whisk it into a salad dressing. Both single-species supplements and multi-mushroom mixtures are available.  

Bonus tip: The active prebiotic components of mushrooms (polysaccharides) are best extracted in water. To benefit from this versatile mushroom’s hydrating and calming properties, it is best to make mushroom tea or combine the mushroom powder with hot water and sip it after a big meal.

FAQs About Turkey Tail Mushroom Gut Health Benefits

Is Turkey Tail A Probiotic?

Turkey tail mushrooms contain prebiotic fiber. Researchers discovered that the mushroom enhances the gut microbiota by acting as a prebiotic and encouraging diversity in the gut. It has been demonstrated that PSK also supports gut health with prebiotics.

Do Turkey Tail Supplements Have Any Side Effects?

The majority of healthy people well tolerate supplements containing Turkey tail. Some patients receiving chemotherapy with polysaccharide krestin (PSK), a chemical derived from turkey tail mushrooms, have complained of nausea, vomiting, low white blood cell counts, and liver issues.

How do I find a high quality Turkey Tail supplement for Gut Health?

A high quality Turkey Tail supplement should be made of 100% fruiting bodies and have beta-glucan amounts clearly stated on the label. Our team of fungi enthusiasts and experts have studied the market and identified the highest quality Turkey Tail producers available in different countries.

For the United States, check out our recommendations of the best quality Turkey Tail mushrooms.

For our Australian readers, please read our guide on the best quality Turkey Tail supplements on the Australian market.

For our readers in Canada, check out our guide on the best quality Turkey Tail supplements in Canada.

Key Takeaways 

The health advantages of Turkey tail for the gut are great, but what’s possibly even more impressive are the long-lasting consequences of a healthy gut on one’s general well-being. One benefit is that it makes it easier for essential nutrients like B12 and vitamin D to be absorbed, which lowers the risk of digestive diseases like colon cancer, colitis, IBS, and Crohn’s disease. However, it has also been demonstrated to boost energy and encourage healthy weight loss.

Do your gut (and every other part of yourself) a favor by enhancing your morning coffee, post-workout smoothie, or an afternoon pick-me-up with Turkey tail mushroom supplements.


  1. https://pubmed.ncbi.nlm.nih.gov/25006989/
  2. https://www.mdpi.com/1422-0067/18/9/1934/htm
  3. https://www.researchgate.net/publication/235717058_Trametes_versicolor_Extract_Modifies_Human_Fecal_Microbiota_Composition_In_vitro
  4. https://pubmed.ncbi.nlm.nih.gov/24019869/  
  5. https://pubmed.ncbi.nlm.nih.gov/15726350/
  6.  https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201801231
  7. https://www.mdpi.com/2076-3921/11/2/406/htm


  • Dr. Sony Sherpa has a Bachelor of Medicine, Bachelor of Surgery (MBBS) from the Guangzhou Medical University and has been studying medicinal mushrooms for more than 7 years. Her knowledge of medicinal mushrooms is backed by a master's degree in Holistic Medicine and contributes to many health articles around the health benefits of medicinal mushrooms.

World Mushroom Society is a collective of fungi enthusiasts and health advocates, sharing information, research, studies, and identifying top producers of high quality medicinal mushroom supplements.


The information on this website is not intended to diagnose, treat, cure or prevent any disease. All information found here is not meant as a substitute for, or alternative to, information from your doctor for ongoing medical treatment you currently receive. If unsure, please consult with your doctor before using medicinal mushrooms. Any content related to cancer should not be considered as prescriptive medical advice and should not be a substitute for any cancer treatment, unless advised by your doctor first. The efficacy of these products has not been confirmed by TGA and FDA-approved research. If you are pregnant or on prescription drugs that thin the blood, consult with your medical professional before using medicinal mushrooms.
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